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sirt1 activator srt1720  (ApexBio)

 
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    ApexBio sirt1 activator srt1720
    Sirt1 Activator Srt1720, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt1 activator srt1720/product/ApexBio
    Average 90 stars, based on 1 article reviews
    sirt1 activator srt1720 - by Bioz Stars, 2026-02
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    The expression of <t>SIRT1</t> in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.
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    sirt1-specific activator srt1720  (Beyotime)
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    The expression of <t>SIRT1</t> in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.
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    sirt1 activator srt1720  (Millipore)
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    The expression of <t>SIRT1</t> in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.
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    sirt1 activator srt1720  (Beyotime)
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    The expression of <t>SIRT1</t> in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.
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    sirt1 activator srt1720  (Selleck Chemicals)
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    Selleck Chemicals sirt1 activator srt1720
    Figure 1. HBO therapy enhanced the decreased expression and activity of spinal cord <t>SIRT1</t> induced by traumatic SCI. (A) The locomotor dysfunction was significantly improved after traumatic SCI rats were applied with series HBO therapy (n = 12/per group). (B) The protein level of spinal cord SIRT1 began to reduce at 8 h (1/3 day) and lasted at least at day 14 after the SCI injury estab lished (n = 4/per group). (C–E) HBO treatment for consecutive 7 days significantly enhanced the decreased protein, mRNA and activity of SIRT1 in spinal cord (n = 5/per group). *p<0.05, **p<0.01, ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 compared with SCI group.
    Sirt1 Activator Srt1720, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt1 activator srt1720/product/Selleck Chemicals
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    sirt1 activator srt1720  (ApexBio)
    90
    ApexBio sirt1 activator srt1720
    Figure 1. HBO therapy enhanced the decreased expression and activity of spinal cord <t>SIRT1</t> induced by traumatic SCI. (A) The locomotor dysfunction was significantly improved after traumatic SCI rats were applied with series HBO therapy (n = 12/per group). (B) The protein level of spinal cord SIRT1 began to reduce at 8 h (1/3 day) and lasted at least at day 14 after the SCI injury estab lished (n = 4/per group). (C–E) HBO treatment for consecutive 7 days significantly enhanced the decreased protein, mRNA and activity of SIRT1 in spinal cord (n = 5/per group). *p<0.05, **p<0.01, ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 compared with SCI group.
    Sirt1 Activator Srt1720, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt1 activator srt1720/product/ApexBio
    Average 90 stars, based on 1 article reviews
    sirt1 activator srt1720 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

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    The expression of SIRT1 in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.

    Journal: Frontiers in Immunology

    Article Title: Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro

    doi: 10.3389/fimmu.2025.1715736

    Figure Lengend Snippet: The expression of SIRT1 in dendritic cells (DCs) was significantly reduced following cigarette smoke treatment when compared with the respective control groups at various time points. Specifically, SIRT1 expression in the CSE-treated DC group was reduced at 12 h, 24 h, 36 h, and 48 h compared to that in the untreated DC group at the corresponding time points (**Comparison with the DC 4 h group, p< 0.01; ***Comparison with the DC 4 h group, p < 0.001; ****Comparison with the DC 4 h group, p < 0.0001; ###Comparison with the DC 12 h group, p < 0.001; $$$$Comparison with the DC 24 h group, p < 0.0001; §§§§Comparison with the DC 36 h group, p < 0.0001; &&&&Comparison with the DC 48 h group, p < 0.0001). For western blot analyses, values are given as mean ± SD of at least three independent experiments (n = 3), and the results were analyzed using unpaired two-tailed Student’s t-tests.

    Article Snippet: The SIRT1 activator SRT1720 was purchased from MedChemexpress (MedChemexpress Biotechnology Company, USA).

    Techniques: Expressing, Control, Comparison, Western Blot, Two Tailed Test

    Data from western blot experiments are given as the mean ± SD of at least three independent experiments (n = 3) for panels (a–h) . Compared with the DC group, **** p < 0.0001. Compared with the SRT1720 + DC group, #### p < 0.0001. Compared with the CSE + DC group, && p < 0.01, &&& p < 0.001, &&&& p < 0.0001. Statistical comparisons were performed using ANOVA followed by the Newman−Keuls post hoc test for multiple comparisons.

    Journal: Frontiers in Immunology

    Article Title: Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro

    doi: 10.3389/fimmu.2025.1715736

    Figure Lengend Snippet: Data from western blot experiments are given as the mean ± SD of at least three independent experiments (n = 3) for panels (a–h) . Compared with the DC group, **** p < 0.0001. Compared with the SRT1720 + DC group, #### p < 0.0001. Compared with the CSE + DC group, && p < 0.01, &&& p < 0.001, &&&& p < 0.0001. Statistical comparisons were performed using ANOVA followed by the Newman−Keuls post hoc test for multiple comparisons.

    Article Snippet: The SIRT1 activator SRT1720 was purchased from MedChemexpress (MedChemexpress Biotechnology Company, USA).

    Techniques: Western Blot

    Figure 1. HBO therapy enhanced the decreased expression and activity of spinal cord SIRT1 induced by traumatic SCI. (A) The locomotor dysfunction was significantly improved after traumatic SCI rats were applied with series HBO therapy (n = 12/per group). (B) The protein level of spinal cord SIRT1 began to reduce at 8 h (1/3 day) and lasted at least at day 14 after the SCI injury estab lished (n = 4/per group). (C–E) HBO treatment for consecutive 7 days significantly enhanced the decreased protein, mRNA and activity of SIRT1 in spinal cord (n = 5/per group). *p<0.05, **p<0.01, ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 compared with SCI group.

    Journal: The International journal of neuroscience

    Article Title: Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

    doi: 10.1080/00207454.2023.2285707

    Figure Lengend Snippet: Figure 1. HBO therapy enhanced the decreased expression and activity of spinal cord SIRT1 induced by traumatic SCI. (A) The locomotor dysfunction was significantly improved after traumatic SCI rats were applied with series HBO therapy (n = 12/per group). (B) The protein level of spinal cord SIRT1 began to reduce at 8 h (1/3 day) and lasted at least at day 14 after the SCI injury estab lished (n = 4/per group). (C–E) HBO treatment for consecutive 7 days significantly enhanced the decreased protein, mRNA and activity of SIRT1 in spinal cord (n = 5/per group). *p<0.05, **p<0.01, ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 compared with SCI group.

    Article Snippet: The SIRT1 activator SRT1720 and inhibitor EX-527 were purchased from Selleck Chemical (Houston, TX) and dissolved in 1% dimethyl sulfoxide (DMSO).

    Techniques: Expressing, Activity Assay

    Figure 2. Administration of SIRT1 antagonist EX-527 reversed the beneficial effects of HBO on locomotor recovery, whereas the SIRT1 agonist SRT1720 had synergic effects on the motor function with HBO therapy. (A-B) The SCI injury rats were applicated with both HBO and EX-527 (i.p.) for continuous 7 days (started at 8h postinjury) got the worse BBB scores compared with those with only administration of HBO and vehicle therapy, while the injury rats treated by HBO and intraperitoneal injection SRT1720 had the higher BBB scores versus those with only administration of HBO and vehicle therapy (n = 12 per group). (C-D) The EX-527 inhibited the enhanced activity of SIRT1 induced by HBO treatment, while SRT1720 increased effects of HBO therapy on the activity of SIRT1(n = 5 per group). *p < 0.05, **p < 0.01compared with SCI + vehicle + HBO group.

    Journal: The International journal of neuroscience

    Article Title: Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

    doi: 10.1080/00207454.2023.2285707

    Figure Lengend Snippet: Figure 2. Administration of SIRT1 antagonist EX-527 reversed the beneficial effects of HBO on locomotor recovery, whereas the SIRT1 agonist SRT1720 had synergic effects on the motor function with HBO therapy. (A-B) The SCI injury rats were applicated with both HBO and EX-527 (i.p.) for continuous 7 days (started at 8h postinjury) got the worse BBB scores compared with those with only administration of HBO and vehicle therapy, while the injury rats treated by HBO and intraperitoneal injection SRT1720 had the higher BBB scores versus those with only administration of HBO and vehicle therapy (n = 12 per group). (C-D) The EX-527 inhibited the enhanced activity of SIRT1 induced by HBO treatment, while SRT1720 increased effects of HBO therapy on the activity of SIRT1(n = 5 per group). *p < 0.05, **p < 0.01compared with SCI + vehicle + HBO group.

    Article Snippet: The SIRT1 activator SRT1720 and inhibitor EX-527 were purchased from Selleck Chemical (Houston, TX) and dissolved in 1% dimethyl sulfoxide (DMSO).

    Techniques: Injection, Activity Assay

    Figure 3. SIRT1 was implicated in the inflammatory cascade induced by traumatic SCI in rats. (A)The enhanced acetylation of NF-κB in SCI rats was remarkably inhibited by HBO treatment (n = 4/per group). (B)The increase of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β and decrease of anti-inflammatory cytokine IL-10 in spinal cord of SCI model rats was revered after the SCI rats was administrated with HBO (n = 5/per group). (C) The effects of HBO treatment on TNF-α, IL-6, IL-1β and IL-10 was blocked by SIRT1 antagonist EX-527 (n = 5/per group). (D) Both application of SIRT1 agonist SRT1720 and HBO promoted the effects of HBO in TNF-α, IL-1β and IL-10 but not IL-6 (n = 5/per group). ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 com pared with SCI group, $$p<0.01 compared with SCI + vehicle + HBO group. SCI + V(SCI + vehicle), SCI + V + H (SCI + vehicle + HBO), SCI + E + H(SCI + EX-527 + HBO), SCI + S + H (SCI + SRT1720 + HBO).

    Journal: The International journal of neuroscience

    Article Title: Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

    doi: 10.1080/00207454.2023.2285707

    Figure Lengend Snippet: Figure 3. SIRT1 was implicated in the inflammatory cascade induced by traumatic SCI in rats. (A)The enhanced acetylation of NF-κB in SCI rats was remarkably inhibited by HBO treatment (n = 4/per group). (B)The increase of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β and decrease of anti-inflammatory cytokine IL-10 in spinal cord of SCI model rats was revered after the SCI rats was administrated with HBO (n = 5/per group). (C) The effects of HBO treatment on TNF-α, IL-6, IL-1β and IL-10 was blocked by SIRT1 antagonist EX-527 (n = 5/per group). (D) Both application of SIRT1 agonist SRT1720 and HBO promoted the effects of HBO in TNF-α, IL-1β and IL-10 but not IL-6 (n = 5/per group). ***p<0.001 compared with sham group, #p<0.05, ##p<0.01 com pared with SCI group, $$p<0.01 compared with SCI + vehicle + HBO group. SCI + V(SCI + vehicle), SCI + V + H (SCI + vehicle + HBO), SCI + E + H(SCI + EX-527 + HBO), SCI + S + H (SCI + SRT1720 + HBO).

    Article Snippet: The SIRT1 activator SRT1720 and inhibitor EX-527 were purchased from Selleck Chemical (Houston, TX) and dissolved in 1% dimethyl sulfoxide (DMSO).

    Techniques:

    Figure 4. HBO modulated the caspase family in a SIRT1-depentent manner. (A) The increase of expression of caspase 1, caspase 3, caspase 8 but not that of caspase 12 in SCI rats was dramatically alleviated following the HBO treatment (n = 4/per group). (B) After application of HBO and SIRT1 antagonist EX-527, the decreased caspase 1, caspase 3 and caspase 8 induced by HBO treat ment was reversed (n = 5/per group). (C) The effects of HBO on the increased expression of caspase 3 and caspase 8 was enhanced following intraperitoneal injection of SIRT1 agonist (n = 5/per group). **p<0.01, ***p<0.001 compared with sham group, #p<0.05, $p<0.05 compared with SCI + vehicle + HBO group. SCI + V(SCI + vehicle), SCI + V + H (SCI + vehicle + HBO), SCI + E + H(SCI + EX-527 + HBO), SCI + S + H (SCI + SRT1720 + HBO).

    Journal: The International journal of neuroscience

    Article Title: Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

    doi: 10.1080/00207454.2023.2285707

    Figure Lengend Snippet: Figure 4. HBO modulated the caspase family in a SIRT1-depentent manner. (A) The increase of expression of caspase 1, caspase 3, caspase 8 but not that of caspase 12 in SCI rats was dramatically alleviated following the HBO treatment (n = 4/per group). (B) After application of HBO and SIRT1 antagonist EX-527, the decreased caspase 1, caspase 3 and caspase 8 induced by HBO treat ment was reversed (n = 5/per group). (C) The effects of HBO on the increased expression of caspase 3 and caspase 8 was enhanced following intraperitoneal injection of SIRT1 agonist (n = 5/per group). **p<0.01, ***p<0.001 compared with sham group, #p<0.05, $p<0.05 compared with SCI + vehicle + HBO group. SCI + V(SCI + vehicle), SCI + V + H (SCI + vehicle + HBO), SCI + E + H(SCI + EX-527 + HBO), SCI + S + H (SCI + SRT1720 + HBO).

    Article Snippet: The SIRT1 activator SRT1720 and inhibitor EX-527 were purchased from Selleck Chemical (Houston, TX) and dissolved in 1% dimethyl sulfoxide (DMSO).

    Techniques: Expressing, Injection

    Figure 6. The enhanced autophagy-related protein by HBO treatment was reduced after administration of EX-527. (A-C) Intraperitoneal injection of SIRT1 antagonist EX-527 abolished the increased expression of pro-autophagy formation-related pro tein (ATG-5, beclin-1, and LC3-2) in SCI rats following the series HBO therapy, (D) while the level of autophagy substrate p62 was upregulated by HBO (n = 5/per group). **p<0.01, ***p<0.001 compared with SCI + vehicle + HBO group.

    Journal: The International journal of neuroscience

    Article Title: Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

    doi: 10.1080/00207454.2023.2285707

    Figure Lengend Snippet: Figure 6. The enhanced autophagy-related protein by HBO treatment was reduced after administration of EX-527. (A-C) Intraperitoneal injection of SIRT1 antagonist EX-527 abolished the increased expression of pro-autophagy formation-related pro tein (ATG-5, beclin-1, and LC3-2) in SCI rats following the series HBO therapy, (D) while the level of autophagy substrate p62 was upregulated by HBO (n = 5/per group). **p<0.01, ***p<0.001 compared with SCI + vehicle + HBO group.

    Article Snippet: The SIRT1 activator SRT1720 and inhibitor EX-527 were purchased from Selleck Chemical (Houston, TX) and dissolved in 1% dimethyl sulfoxide (DMSO).

    Techniques: Injection, Expressing